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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:

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Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 363-370 doi: 10.1007/s11684-010-0210-7

Abstract: Chemical biology, using small molecules as probes to study the cellular signaling network, has developedThe interaction between chemistry and biology not only provides new insight into the understanding of

Keywords： protein degradation leukemia chemical biology transcription factors oncoprotein

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A Prospect on Research and Application of Natural Toxins

Chen Yisheng

Strategic Study of CAE 2003, Volume 5, Issue 2, Pages 16-19

Abstract:

Toxins are biogenic chemical substances with meaningful value.They display plentiful diversities in many aspects such as biogenity, chemical structure, biologicaldisciplinary subject , develops rapidly in recent decades, the advances in which are pushing effect on chemicalbiology, chemical ecology, biogenic syntheses, life science, environment science and medicine.

Keywords： natural toxins diversity in natural toxins control of biological toxicosis biogenic syntheses chemicalbiology chemical ecology new drug research

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1044-4

Abstract: As of May 3, 2023, the coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndrome. The primary etiology may be attributed to cytokine storm, which is triggered by the excessive release of proinflammatory cytokines and subsequently leads to immune dysregulation. Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenic coronavirus-infected diseases, such as severe acute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6 pathway has emerged as a key in the pathogenesis of this hyperinflammatory state. Thus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate the pivotal role played by tocilizumab in combating COVID-19.

Keywords： SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab

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Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 139-142 doi: 10.1007/s11705-017-1636-0

Abstract: typical topic of synthetic biology.

Keywords： synthetic biology enzyme evolutionary engineering polyhydroxyalkanoate

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Special issue on “Green chemical process and intensification”

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 11, Pages 1533-1535 doi: 10.1007/s11705-022-2263-y

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Special Issue for the Future Chemical Engineering Scholars of Global Chinese Chemical Engineering Symposium

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6, Pages 775-776 doi: 10.1007/s11705-022-2172-0

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract:

Lung cancer is the leading cause of cancer-related deaths in the US and worldwide. Better understanding of the disease is warranted for improvement in clinical management. Here we summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lung cancers. We discuss the microRNAs that play oncogenic as well as tumor suppressive roles. We also touch on the value of microRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung cancers.

Keywords： lung biology lung cancer microRNA

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Insight of chemical environmental risk and its management from the vinyl chloride accident

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 4, doi: 10.1007/s11783-023-1652-x

Abstract: Finally, this accident suggests that further efforts should be taken to bridge the gap between chemical

Keywords： Vinyl chloride Combustion Chemical safety management Environmental risk Emerging contaminants

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Effects of sulfur on variations in the chemical speciation of heavy metals from fly ash glass

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1728-7

Abstract:

● A higher sulfur content reduced the curing rate of Cr in glass.

Keywords： Dechlorinated fly ash SO₃ Heavy metal Chemical speciation Glass solidification

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New Trend of Forest Chemical Industry in China

Song Zhanqian

Strategic Study of CAE 2001, Volume 3, Issue 2, Pages 1-6

Abstract:

Forest chemical industry can produce various useful products by chemical processing of forest resourcesThe present conditiobns of the forest chemical industry in China was reviewed in this paper.

Keywords： forest chemical industry forest resource chemical processing

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Bioinspired and biomimetic membranes for water purification and chemical separation: A review

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1412-8

Abstract:

•The history of biological and artificial water channels is reviewed.

Keywords： Aquaporins Artificial water channels Biomimetic membranes Chemical separation and water purification

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Chemical transdifferentiation: closer to regenerative medicine

Aining Xu,Lin Cheng

Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 152-165 doi: 10.1007/s11684-016-0445-z

Abstract: Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which isDespite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely

Keywords： cell therapy cell transdifferentiation chemical compounds small molecules tissue regeneration

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Computational design of structured chemical products

Faheem Mushtaq, Xiang Zhang, Ka Y. Fung, Ka M. Ng

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5, Pages 1033-1049 doi: 10.1007/s11705-020-2002-1

Abstract: In chemical product design, the aim is to formulate a product with desired performance.performance, ingredients, structure, and manufacturing process framework for the design of structured chemical

Keywords： product design performance ingredients structure manufacturing process framework structured chemical

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Hexachlorobutadiene emissions from typical chemical plants

Minxiang Wang, Lili Yang, Xiaoyun Liu, Zheng Wang, Guorui Liu, Minghui Zheng

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1352-8

Abstract: Abstract • Unintentional HCBD production in typical chemical plants was investigated. • The highestFew studies of HCBD formation during chemical production processes have been performed, so HCBD emissionsstudy, HCBD concentrations in raw materials, intermediate products, products, and bottom residues from chemicalThe concentrations in the bottom residue samples contributed 24%–99% of the total HCBD formed in the chemicalThe results indicate the concentrations of HCBD unintentionally produced in typical chemical plants and

Keywords： Hexachlorobutadiene Chemical plant Chlorobenzene Trichloroethylene Tetrachloroethylene